Published Work

2019

Reddy KC, Dror T, Underwood RS, Osman GA, Elder CR, Desjardins CA, Cuomo CA, Barkoulas M, Troemel ER. Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegansPLoS Pathog. 2019 Jan 14;15(1):e1007528. 

2018

 Osman GA, Fasseas MK, Koneru SL, Essmann CL, Kyrou K, Srinivasan MA, Zhang, Sarkies P, Félix M-A and Barkoulas M. Natural infection of C. elegans by an oomycete reveals a new pathogen-specific immune response. Curr Biol 2018, 28, 640–648

2017

 Katsanos D., Koneru S.L., Mestek Boukhibar L.,Gritti N., Ghose R., Appleford P.J, Doitsidou M., Woollard A., van Zon J.S , Poole R.J and Barkoulas M. (2017). Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number. PLoS Biol Nov 6;15(11):e2002429

2016

Barkoulas M*, Vargas Velazquez AM, Peluffo AE, Félix MA. Evolution of new cis-regulatory motifs required for cell-specific gene expression in Caenorhabditis. PLoS Genetics 2016 Sep 2;12(9):e1006278

2015

Matus DQ, Lohmer LL, Kelley LC, Schindler AJ, Kohrman AQ, Barkoulas M, Zhang W, Chi Q, Sherwood DR. Invasive cell fate requires G1 cell-cycle arrest and histone deacetylase-mediated changes in gene expression. Dev Cell. 2015 Oct 26;35(2):162-74 

van Zon JS, Kienle S, Huelsz-Prince G, Barkoulas M, van Oudenaarden A.Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression. Nat Commun 2015 May 11;6:7053. 

Félix MA, Barkoulas M. Pervasive robustness in biological systems.  Nat Rev Genet. 2015 Aug;16(8):483-96.

Mestek Boukhibar L, Barkoulas M. The developmental genetics of biological robustness.  Ann Bot. 2015Apr;117(5):699-707.

2014 and before

Hay AS, Pieper B, Cooke E, Mandáková T, Cartolano M, Tattersall AD, Ioio RD, McGowan SJ, Barkoulas M, Galinha C, Rast MI, Hofhuis H, Then C, Plieske J, Ganal M, Mott R, Martinez-Garcia JF, Carine MA, Scotland RW, Gan X, Filatov DA, Lysak MA, Tsiantis M. Cardamine hirsuta: a versatile genetic system for comparative studies. Plant Journal 2014 Apr;78(1):1-15.

Barkoulas M., van Zon J.S., Milloz J., van Oudenaarden A., and Félix M.-A. Robustness and epistasis in the C. elegans vulval signaling network revealed by pathway dosage modulation. Dev Cell 2013 Jan 14;24(1):64-75

Félix M.-A., Barkoulas M. Robustness and flexibility in nematode vulva development. Trends in Genetics 2012 28 (4): 185-195 

Hoyos E., Kim K., Milloz J., Barkoulas M., Pénigault J-B., Munro E., Félix M-A. Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network. Curr Biol 2011 21 (7): 527 – 538.

Bilsborough G.D.*, Runions A.*, Barkoulas M.*, Jenkins H.W, Hasson A., Galinha C., Laufs P., Hay A., Prusinkiewicz P., and Tsiantis M. Model for the regulation of Arabidopsis thalianaleaf margin development. PNAS 2011 108 (8): 3424-3429. 

Prasad K., Grigg S.P*, Barkoulas M.*, Ram Kishor Yadav, Gabino F. Sanchez-Perez, Violaine Pinon, Blilou I., Hofhuis H., Dhonukshe P., Galinha C., Mähönen A.P, Muller W.H, RamanS., Verkleij A.J, SnelB., Reddy G.V, Tsiantis M., Scheres B. Arabidopsis PLETHORA transcription factors control phyllotaxis. Curr Biol 2011 21 (13): 1123-1128. 

Scarpella E., Barkoulas M., Tsiantis M. Control of leaf and vein development by auxin. Cold Spring Harb Perspect Biol. 2010 2(1): a001511.

Canales C., Barkoulas M., Galinha C., Tsiantis M. Weeds of change: Cardamine hirsuta as a new model system for studying dissected leaf development. J Plant Res. 2010 123 (1): 25-33.

Barkoulas M., Hay A., Kougioumoutzi E. and Tsiantis M.A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta. Nature Genetics 2008 40(9): 1136-1141.

 

Barkoulas M., Galinha C., Grigg S.P., Tsiantis M. From genes to shape: regulatory interactions in leaf development. Curr Opin Plant Biol. 2007 10 (6): 660-6. 

 

Hay A., Barkoulas M.* and Tsiantis M. ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis. Development2006 133 (20): 3955-3961. 

 

Hay A., Barkoulas M., Tsiantis M. PINning down the connections: transcription factors and hormones in leaf morphogenesis. Curr Opin Plant Biol 2004 7 (5):575-81

2020

Hintze M, Koneru SL, Gilbert SPR, Katsanos D, Lambert J and Barkoulas M. A cell fate switch intheC. elegansseam cell lineage occurs through modulation of the Wnt asymmetry pathway in response to temperature increase. Genetics 2020 April 1, 2020 vol. 214 no. 4 927-939. Brief video explaining this work here https://youtu.be/4FGWhJSLXe0